Derivatives of heteroarylsulfonamides, their prepa

专利名称：Derivatives of heteroarylsulfonamides, their

preparation and their application in humantherapy

发明人：Elisabeth Dupont-Passelaigue,Isabelle Le

Roy,Christophe Pignier

申请号：US14460951申请日：20140815公开号：US09156834B2公开日：20151013

摘要：The present invention concerns derivatives of heteroarylsulfonamides, notablyas blockers of Kv potassium channels, and more particularly of channels Kv1.5, Kv4.3 orKv11.1, their application in clinical therapy and their preparation methods. These

compounds correspond to the following general formula (I): where R1 represents one ormore substituents of the phenyl core X such as: hydrogen, halogen, trifluoromethyl,trifluoromethoxy, linear or branched C-Calkyl, or linear or branched C-Calkoxy, Arepresents oxygen or sulphur, B represents nitrogen when n=1 or 2 and D represents —C(═O)—, or B represents CH when n=0 and D represents —CHO— or when n=1 and Drepresents —O—, R2 represents a hydrogen, a methyl, a fluorine or chlorine atom or amethoxy, HetAr represents a pyridyl or quinolyl group, possibly substituted by a groupsuch as a linear or branched C-Calkyl, a linear or branched C-Calkoxy, a halogen, or atrifluoromethyl, and to their pharmaceutically acceptable salts.

申请人：PIERRE FABRE MEDICAMENT

地址：Boulogne-Billancourt FR

国籍：FR

代理机构：Birch, Stewart, Kolasch & Birch, LLP

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